FIND DOCTORS
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Name:Jia,LiJun
Department: Cancer Institute
Title:ProfessorEducation & Professional Experience Dr. Jia received his bachelor degree of Veterinary Medicine in Northeast Agricultural University in 1997. He got his Ph.D. degree of Preventive Veterinary Medicine in Yangzhou University in 2003. Then he received his postdoctoral training in Life Science School of Nanjing University during 2003-2005 and Medical School of University of Michigan during 2005-2010. In April 2010, he joined in Fudan University as a professor and a Principle Investigator at Cancer Institute, Shanghai Cancer Center. Specialty Anticancer target identification; Cancer targeted therapy. Research Dr. Jia has been focusing on the identification and validation of anticancer targets against protein modification pathways. He successfully identified and validated ROC1, the core component of CRL ubiquitin ligase, as a novel anticancer target, which provides solid scientific basis for drug discovery against ROC1. Meanwhile, he demonstrated the overexpression of neddylation pathway in human cancers. Moreover, he illuminated several important anti-cancer mechanisms of inhibition of neddylation-CRL axis, which significantly facilitates the development of neddylation-CRL inhibitors for the treatment of cancer. So far, he has published 40 articles in the academic journals, including J Natl Cancer Inst, Cancer Research, Autophay, Cell Death & Differentiation, Mol Cell Proteomics, etc. His studies have been funded by several National Natural Science Foundation of China (31071204，30500637，81172092) and National Basic Research Program of China (973 program, 2012CB910300). Publication Selected papers
1.Junfeng Xu, Lihui Li, Guangyang Yu, Wantao Ying, Qiang Gao,Wenjuan Zhang, Xianyu Li, Chen Ding, Yanan Jiang, Dongping Wei,Shengzhong Duan, Qunying Lei, Peng Li, Tieliu Shi, Xiaohong Qian, Jun Qin, Lijun Jia. Neddylation-Cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer. Mol Cell Proteomics. 2015,14:499-509. doi:10.1074/mcp.M114.045211
2. Ping Chen, Tao Hu,Yupei Liang, Yongfu Pan, Yanan Jiang, Chunjie Li, Ping Zhang, Dongping Wei, Pei Li, Lak Shin Jeong, Yiwei Chu, Hui Qi, Meng Yang, Robert M. Hoffman, Ziming Dong, Lijun Jia. Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer. Oncotarget. 2015, Mar 13. [Epub ahead of print]
3.Wei Hua?, Chunjie Li?, Zixiao Yang, Lihui Li, Yanan Jiang, Guangyang Yu,Wei Zhu, Zhengyan Liu, Shengzhong Duan,Yiwei Chu, Meng Yang, Yanmei Zhang, Ying Mao, and Lijun Jia. Suppression of glioblastoma by targeting the overactivated protein neddylation pathway. Neuro-Oncology 2015; Apr 22. doi:10.1093/neuonc/nov066
4.Yanchun Wang, Zhongguang Luo, Yongfu Pan, Weige Wang, Xiaoyan Zhou, Lak Shin Jeong, Yiwei Chu, Jie Liu, Lijun Jia. Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. Cancer Biology and Therapy. 2015, 16:420-9
5.Jiang Y, Jia L. Neddylation Pathway as a Novel Anti-Cancer Target: Mechanistic Investigation and Therapeutic Implication. Anticancer Agents Med Chem. 2015, Mar 4. [Epub ahead of print]
6.Lihui Li, Mingsong Wang, Guangyang Yu, Ping Chen, Hui Li, Dongping Wei, Ji Zhu, Li Xie, Huixun Jia, Jieyi Shi, Chunjie Li, Wantong Yao, Yanchun Wang, Qiang Gao, Lak Shin Jeong, Hyuk Woo Lee, Jinha Yu, Fengqing Hu, Ju Mei, Ping Wang, Yiwei Chu, Hui Qi, Meng Yang, Ziming Dong, Yi Sun, Robert M. Hoffman, Lijun Jia. Overactivated neddylation pathway as a therapeutic target in lung cancer. Journal of the National Cancer Institute (JNCI), 2014, 106:dju083. doi: 10.1093/jnci/dju083
7.Qiang Gao, Guang-Yang Yu, Jie-Yi Shi, Li-Hui Li, Wen-Juan Zhang, Zhi-Chao Wang, Liu-Xiao Yang, Meng Duan, Hu Zhao, Xiao-Ying Wang, Jian Zhou, Shuang-Jian Qiu, Lak Shin Jeong, Li-Jun Jia, and Jia Fan. Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. Oncotarget. 2014, 5:7820-32.（Co-corresponding author）
8.Wang X, Li L, Liang Y, Li C, Zhao H, Ye D, Sun M, Jeong LS, Feng Y, Fu S, Jia L, Guo X.Targeting the Neddylation Pathway to Suppress the Growth of Prostate Cancer Cells: Therapeutic Implication for the Men's Cancer. Biomed Res Int. 2014 doi: 10.1155/2014/974309. （Co-corresponding author）
9.Wan-Tong Yao, Jian-Fu Wu, Guang-Yang Yu, Rui Wang, Kai Wang, Li-Hui Li, Ping Chen, Ya-Nan Jiang, He Cheng ,Hyuk Woo Lee, Jinha Yu, Hui Qi, Xian-Jun Yu, Ping Wang, Yi-Wei Chu, Meng Yang, Zi-Chun Hua, Hao-Qiang Ying, Robert M. Hoffman, Lak Shin Jeong, Li-Jun Jia. Suppression of tumor angiogenesis by targeting protein neddylation pathway. Cell Death & Disease, 2014, e1059. doi: 10.1038/cddis.2014.21
10.Hua Li, Mingjia Tan, Lijun Jia, Guoan Chen, Yongchao Zhao, Lili Zhao, Dafydd Thomas, David Beer, Yi Sun. Inactivation of Sag/Rbx2/Roc2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. Journal of Clinical Investigation. 2014, 124:835-46
11.Dongqin Yang, Lihui Li, Hui Liu, Lijun Wu, Zhongguang Luo, Haixia Li, Shimin Zheng, Haifeng Gao , Yiwei Chu ,Yi Sun, Jie Liu, Lijun Jia. Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells. Cell Death & Differentiation, 2013, 20:235-47
12.Ding C, Jiang J, Wei J, Liu W, Zhang W, Liu M, Fu T, Lu T, Song L, Ying W, Chang C, Zhang Y, Ma J, Wei L, Malovannaya A, Jia L, Zhen B, Wang Y, He F, Qian X, Qin J. A fast workflow for identification and quantification of proteomes. Mol Cell Proteomics. 2013;12: 2370-80
13.Lihui Li, Binghong Liu, Tiangeng Dong, Hyuk Woo Lee, Jinha Yu,Yijie Zheng, Haifeng Gao, Yan Zhang, Yiwei Chu, Guangwei Liu, Weixin Niu, Shimin Zheng, Lak Shin Jeong, Lijun Jia. Neddylation pathway regulates the proliferation and survival of macrophages. Biochem Bioph Res Co. 2013;432:494-8
14.Dongqin Yang, Yongchao Zhao, Jie Liu, Yi Sun, Lijun Jia. Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis . Autophagy, 2012,8:1856-8
15.Zhongguang Luo, Guangyang Yu,Hyuk Woo Lee,Lihui Li, Lingyan Wang, Dongqin Yang, Yongfu Pan, Chan Ding,Jing Qian, Lijun Wu, Yiwei Chu, Jing Yi, Xiangdong Wang, Yi Sun, Lak Shin Jeong,Jie Liu, Lijun Jia.An NEDD8-Activating Enzyme inhibitor MLN4924 suppresses the growth of hepatocellular carcinoma cells by modulating autophagy and apoptosis. Cancer Research, 2012, 72:3360-3371
16.Zhongguang Luo, Yongfu Pan, Lak Shin Jeong, Jie Liu, Lijun Jia. Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells. Autophagy, 2012, 8:1677-1679
17.Yongchao Zhao , Xiufang Xiong , Lijun Jia, Yi Sun. Targeting Cullin-RING ligases by MLN4924 induces autophagy by modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease, 2012, 3:e386. doi: 10.1038/cddis.2012.125.
18.Pan Y, Xu H, Liu R, Jia L*. Induction of cell senescence by targeting to Cullin-RING Ligases (CRLs) for effective cancer therapy. Int J Biochem Mol Biol. 2012;3(3):273-81.
19.Mingjia Tan, Yongchao Zhao, Sun-Jung Kim，Margaret Liu, Lijun Jia, Thomas Saunders, Yuan Zhu, and Yi Sun. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF-1 for degradation. Developmental Cell, 2011, 21: 1-15
20.Lijun Jia, Jeremy Bickel , Jiaxue Wu , Meredith Morgan , Hua Li , Jie Yang , Xiaochun Yu , Raymond Chan , Yi Sun. RBX1 E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. JBC. 2011，286：3379-86 (Co-corresponding author)
21.Lijun Jia, Hua Li, Yi Sun. Induction of p21-dependent senescence by a NAE inhibitor, MLN4924 as a mechanism of growth suppression. Neoplasia,2011, 13:563-569. (Co-corresponding author)
22.Lijun Jia, Yi Sun. SCF E3 ubiquitin ligase as anticancer target. Current Cancer Drug Targets, 2011;11:347-56.
23.Lijun Jia, Jie Yang , Xinbao Hao, Min Zheng, Hongbin He, Xiufang Xiong, Liang Xu and Yi Sun. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anti-cancer and radio-sensitizing target. Clin Cancer Res. 2010;16:814-24
24.Lijun Jia, Maria S. Soengas, Yi Sun. ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2/M arrest, apoptosis, and senescence. Cancer Research，2009;69:4974-82
25.Zhen Wang, Min Zheng, Zhichuan Li, Ruiguo Li, Lijun Jia, Xiufang Xiong, Noel Southall, Shaomeng Wang, Christopher P. Austin, Wei Zheng, Zijian Xie, and Yi Sun. Cardiac glycosides inhibit p53 protein synthesis via activating Src/MAPK signaling pathways. Cancer Research, 2009, 69:6556-64
26.Chen G, Wei DP, Jia LJ, Tang B, Shu L, Zhang K, Xu Y, Gao J, Huang XF, Jiang WH, Hu QG, Huang Y, Wu Q, Sun ZH, Zhang JF, Hua ZC*. Oral delivery of tumor-targeting Salmonella exhibits promising therapeutic efficacy and low toxicity. Cancer Sci, 2009 ; 100: 2437-43. (Co-corresponding author)
27.Lijun Jia, Yi Sun. SCF F-box protein FBXO31 and FBX4 in the regulation of cyclin D1 degradation upon DNA damage. Pigment Cell Melanoma Res, 2009 ;22:518-9
28.Lijun Jia, Yi Sun. RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival. Cell Division, 2009, 4:1-5
29.Lijun Jia, Genggeng Yu, Michael Wang. Lysosome-dependent degradation of Notch3. International Journal of Biochemistry & Cell Biology， 2009，41:2594-8
30.Yanmei Zhang, Lijun Jia, Soo Jun Lee, Michael Wang. Conserved Notch3 signal peptide inhibits cytoplasmic interactions. Biochem Bioph Res Co, 355:245-51,2007
31.Lijun Jia, Dongping Wei, Qiming Sun, Guanghui Jin, Shufeng Li, Yan Huang, Zichun Hua.Tumor-targeting Salmonella typhimurium improves cyclophosphamide chemotherapy at maximum tolerated dose and low-dose metronomic regimens in a murine melanoma model. Int J Cancer ,2007, 121:666-74
32.Lijun Jia, Dongping Wei, Qiming Sun, Yan Huang, Zichun Hua. Oral delivery of tumor-targeting Salmonella for cancer therapy in murine tumor models. Cancer Science, 2007, 98:1107-12
33.Lijun Jia, Hanmei Xu, Dingyuan Ma, Qingang Hu, Xiaofeng Huang, Wenhui Jiang, Shufeng Li, Kunzhi Jia, Qilai Huang, Zichun Hua. Enhanced Therapeutic Effect by Combination of Tumor-Targeting Salmonella and Endostatin in Murine Melanoma Model. Cancer Biology & Therapy, 2005, 4:840-5Awards Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning;
Shanghai Pujiang Talent;
Shanghai Shuguang Talent;
Distinguished Young Scholars of Fudan University Shanghai Cancer Center.Out-patient Schedule
