FIND DOCTORS
-
Name:Liu,Suling
Department: Cancer Institute
Title: ProfessorEducation & Professional Experience Ph.D. in Molecular and Cellular Biology, The Ohio State University, Columbus, OH, USA. 2003 B.S. in Biology, University of Science and Technology of China, Hefei, Anhui, China. 1997
Research Nov. 2012~Present, Professor, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
Characterizing different states of breast cancer stem cells.
Studying the effects of microRNAs on breast cancer stem cell self-renewal and differentiation using Tet-on/off system, mammary fatpad injections and intracardiac injections in mouse models.
Studying the regulation of tumor microenvironment on breast cancer stem cell.
Oct. 2010~Oct. 2012, Research Assistant Professor, Department of Internal Medicine / Comprehensive Cancer Center, University of Michigan, Ann Arbor, USA.
Investigating the combination therapy of PARPi and 17-AAG to target breast cancer stem cells in Triple-negative breast cancers
Studying the effects of microRNAs on breast cancer stem cell self-renewal and differentiation using Tet-on/off system, mammary fatpad injections and intracardiac injections in mouse models
Oct. 2006~Oct. 2010, Research Investigator, Department of Internal Medicine / Comprehensive Cancer Center, University of Michigan, Ann Arbor, USA.
Studying the effects of microRNAs on breast cancer stem cell differentiation using
Tet-on/off system, mammary fatpad injections and intracardiac injections in mouse
models
Studying the microenvironment (“niche”) of human breast stem cells in both in vitro
co-culture system and in vivo intra-tibia injections
Utilizing lentiviral siRNA system to study the role of BRCA1 in human breast stem cell
self-renewal and differentiation in both in vitro and in vivo models
Oct. 2003~Sept. 2006, Research Fellow, Department of Internal Medicine / Comprehensive Cancer Center, University of Michigan, Ann Arbor, USA.
Utilizing lentiviral systems (knockdown or overexpression) to study the role of
Hedgehog pathway, Notch Pathway and Bmi-1 in human breast stem cell
self-renewal and differentiation both in vitro “mammosphere” system and in vivo
NOD/SCID mouse model
Identification and Isolation of both normal and cancerous human breast stem cells
with cell surface markers by flow cytometry
Mar. 1999~Sept.2003, Graduate student Research Assistant, Department of Vet. Biosciences, The Ohio State University, Columbus, OH, USA
Studying the risk of exposure to beef growth promoter in breast cancer
Defining the estrogenic regulation mechanism and function of Protein Tyrosine
Phosphatse (PTP) gamma, a novel tumor suppressor gene in human breast
Indentifying the anticancer potential of a natural compound, Gossypol (GP), and its enatiomers, (+)GP and (-)GP, in human breast cancerPublication Articles in peer-reviewed journals
1.Liu, Y., Burness, M.L., Martin-Trevino, R., Guy, J., Bai, S., Harouaka, R., Brooks, M.D., Shang, L., Fox, A., Luther, T.K., Davis, A., Baker, T.L., Colacino, J., Clouthier, S.G., Shao, Z-M., Wicha, M.S., and Liu, S*. RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer. Clinical Cancer Research (In press), 2017.
2.Liu, R., Shi, P., Nie, Z., Liang, H., Zhou, Z., Chen, W., Chen, H., Dong, C., Yang, R., Liu, S., Chen, C.* Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression. Theranostics 6(4):533-544, 2016.
3.Xu, B., Du, W.Q., Li, J.W., Hu, Y.L.*, Yang, L., Zhang, C.C., Li, G.Q., Lao, Z.X., Ni, J.C.,Chu, J.R., Wu, D.*, Liu, S., Sugioka, K. High efficiency integration of three-dimensional functional microdevices inside a microfluidic chip by using femtosecond laser multifoci parallel microfabrication. Scientific Reports 6, 2016. PMID: 26818119.
4.Zhao, Z., Li, S., Song, E., and Liu, S*. The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells. Protein & cell 7, 89-99,2016. PMID:26349457.
5.Liu, Y., Chen, C., Qian, P., Lu, X., Sun, B., Zhang, X., Wang, L., Gao, X., Li, H., Chen, Z., Tang, J., Zhang, W., Dong, J., Bai, R., Lobie, P. E., Wu, Q., Liu, S., Zhang, H., Zhao, F., Wicha, M. S., Zhu, T., and Zhao, Y. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nature Communications 6:5988, 2015. PMID:25612916.
6.Ke, J.*, Zhao, Z., Hong, S.-H., Bai, S., He, Z., Malik, F., Xu, J., Zhou, L., Chen, W., Martin-Trevino, R., Wu, X., Lan, P., Yi, Y., Ginestier, C., Ibarra, I., Shang, L., McDermott, S., Luther, T., Clouthier, S. G., Wicha, M. S.*, and Liu, S*. Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells. Oncotarget 6, 3709-3721, 2015. PMID:25686829.
7.Sun, S., Liu, S., Duan, S. Z., Zhang, L., Zhou, H., Hu, Y., Zhou, X., Shi, C., Zhou, R., and Zhang, Z*. Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas. Cancer Research 74, 7546-7559, 2014. PMID:25320014.
8.Lombardi, S., Honeth, G., Ginestier, C., Shinomiya, I., Marlow, R., Buchupalli, B., Gazinska, P., Brown, J., Catchpole, S., Liu, S., Barkan, A., Wicha, M., Purushotham, A., Burchell, J., Pinder, S., and Dontu, G*. Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells. Stem Cell Reports 2, 780-793, 2014. PMID:24936466.
9.Liu, S.*, Cong, Y., Wang, D., Sun, Y., Deng, L., Liu, Y., Martin-Trevino, R., Shang, L., McDermott, S. P., Landis, M. D., Hong, S., Adams, A., D'Angelo, R., Ginestier, C., Charafe-Jauffret, E., Clouthier, S. G., Birnbaum, D., Wong, S. T., Zhan, M., Chang, J.C.*, and Wicha, M.S.* Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts. Stem Cell Reports 2, 78-91,2014. PMID:24511467.
10.Ding, K., Banerjee, A., Tan, S., Zhao, J., Zhuang, Q., Li, R., Qian, P., Liu, S., Wu, Z.-S., Lobie, P. E., and Zhu, T*. Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells. Journal of Biological Chemistry 289, 16057-16071, 2014. PMID:24737320.
11.Deng, L., Shang, L., Bai, S., Chen, J., He, X., Martin-Trevino, R., Chen, S., Li, X.-Y., Meng, X., Yu, B., Wang, X., Liu, Y., McDermott, S. P., Ariazi, A. E., Ginestier, C., Ibarra, I., Ke, J., Luther, T., Clouthier, S. G., Xu, L., Shan, G., Song, E., Yao, H., Hannon, G. J., Weiss, S. J., Wicha, M. S., and Liu, S*. MicroRNA100 Inhibits Self-Renewal of Breast Cancer Stem-like Cells and Breast Tumor Development. Cancer research 74, 6648-6660, 2014. PMID:25217527.
12.Luo, M., Zhao, X., Chen, S., Liu, S., Wicha, M. S., and Guan, J.-L.* Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics. Cancer Research 73, 5591-5602, 2013. PMID:23832665.
13.Wu, J., Liu, S., Liu, G., Dombkowski, A., Abrams, J., Martin-Trevino, R., Wicha, M.S.*, Ethier, S. P., and Yang, Z.-Q. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene 31, 333-341, 2012. PMID:21666724.
14.Liu, S.*, Patel, S. H., Ginestier, C., Ibarra, I., Martin-Trevino, R., Bai, S., McDermott, S. P., Shang, L., Ke, J., Ou, S. J., Heath, A., Zhang, K. J., Korkaya, H., Clouthier, S. G., Charafe-Jauffret, E., Birnbaum, D., Hannon, G. J., and Wicha, M.S*. MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells. Plos Genetics 8(6),2012. PMID:22685420.
15.Liu, S., Korkaya, H., and Wicha, M.S.* ARE CANCER STEM CELLS READY FOR PRIME TIME? Scientist 26, 32-37,2012.
16.Liu, S., Clouthier, S. G., and Wicha, M.S.* Role of microRNAs in the Regulation of Breast Cancer Stem Cells. Journal of Mammary Gland Biology and Neoplasia 17, 15-21,2012. PMID:22331423.
17.Kryczek, I., Liu, S., Roh, M., Vatan, L., Szeliga, W., Wei, S., Banerjee, M., Mao, Y., Kotarski, J., Wicha, M. S., Liu, R., and Zou, W.* Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. International Journal of Cancer 130, 29-39,2012. PMID:21480217.
18.Korkaya, H., Kim, G.-i., Davis, A., Malik, F., Henry, N. L., Ithimakin, S., Quraishi, A. A., Tawakkol, N., D'Angelo, R., Paulson, A. K., Chung, S., Luther, T., Paholak, H. J., Liu, S., Hassan, K. A., Zen, Q., Clouthier, S. G., and Wicha, M.S.* Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+Breast Cancer by Expanding the Cancer Stem Cell Population. Molecular Cell 47, 570-584,2012. PMID:22819326.
19.Liu, S.*, Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., Jung, Y., Dontu, G., Taichman, R., and Wicha, M.S.* Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Research 71, 614-624,2011. PMID:21224357.
20.Korkaya, H., Liu, S., and Wicha, M.S.* Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots. Clinical Cancer Research 17, 6125-6129,2011. PMID:21685479.
21.Korkaya, H., Liu, S., and Wicha, M.S.* Breast cancer stem cells, cytokine networks, and the tumor microenvironment. Journal of Clinical Investigation 121, 3804-3809,2011. PMID:21965337.
22.Shu, S. T., Sugimoto, Y., Liu, S., Chang, H.-L., Ye, W., Wang, L.-S., Huang, Y.-W., Yan, P., and Lin, Y. C. Function and Regulatory Mechanisms of the Candidate Tumor Suppressor Receptor Protein Tyrosine Phosphatase Gamma (PTPRG) in Breast Cancer Cells. Anticancer Research 30, 1937-1946,2010. PMID:20651337.
23.Liu, S., and Wicha, M. S. Targeting Breast Cancer Stem Cells. Journal of Clinical Oncology 28, 4006-4012,2010. PMID:20498387.
24.Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H.-F., Newman, B., Yu, Y., Clouthier, S. G., Schwartz, S. J., Wicha, M. S., and Sun, D. Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells. Clinical Cancer Research 16, 2580-2590,2010. PMID:20388854.
25.Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G., and Wicha, M. S. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Research and Treatment 122, 777-785,2010. PMID:19898931.
26.Ginestier, C., Liu, S., Diebel, M. E., Korkaya, H., Luo, M., Brown, M., Wicinski, J., Cabaud, O., Charafe-Jauffret, E., Birnbaum, D., Guan, J.-L., Dontu, G., and Wicha, M. S. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. Journal of Clinical Investigation 120, 485-497,2010. PMID:20051626.
27.Luo, M., Fan, H., Nagy, T., Wei, H., Wang, C., Liu, S., Wicha, M. S., and Guan, J.-L. Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells. Cancer Research 69, 466-474,2009. PMID:19147559.
28.Gur, D., Liu, S., Shukla, A., Pero, S. C., Wicha, M. S., and Krag, D. N. Identification of Single Chain Antibodies to Breast Cancer Stem Cells Using Phage Display. Biotechnology Progress 25, 1780-1787,2009. PMID:19899107.
29.Ginestier, C., Liu, S., and Wicha, M. S. Getting to the Root of BRCA1-Deficient Breast Cancer. Cell Stem Cell 5, 229-230,2009. PMID:19733528.
30.Chang, H.-L., Sugimoto, Y., Liu, S., Wang, L.-S., Huang, Y.-W., Ye, W., and Lin, Y. C. Keratinocyte Growth Factor (KGF) Regulates Estrogen Receptor-alpha (ER-alpha) Expression and Cell Apoptosis via Phosphatidylinositol 3-kinase (PI3K)/Akt Pathway in Human Breast Cancer Cells. Anticancer Research 29, 3195-3205,2009. PMID:19661335.
31.Wang, L.-S., Huang, Y.-W., Liu, S., Yan, P., and Lin, Y. C. Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue. Bmc Cancer 8:208-221,2008. PMID:18652667.
32.Liu, S., Ginestier, C., Charafe-Jauffret, E., Foco, H., Kleer, C. G., Merajver, S. D., Dontu, G., and Wicha, M. S. BRCA1 regulates human mammary stem/progenitor cell fate. Proceedings of the National Academy of Sciences of the United States of America 105, 1680-1685,2008. PMID:18230721.
33.Updike, M. S., Sawdy, J. C., Wang, L.-S., Liu, S., Huang, Y.-W., Ye, W., Farrar, W. B., Lin, Y. C., and Wick, M. Primary cultured human breast epithelial cells up-regulate protein disulfide isomerase in response to zeranol. Anticancer Research 27, 407-410,2007. PMID:17352260.
34.Ginestier, C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C. G., Liu, S., Schott, A., Hayes, D., Birnbaum, D., Wicha, M. S., and Dontu, G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-567,2007. PMID:18371393.
35.Wicha, M., Liu, S., and Dontu, G. Cancer stem cells: An old idea - A paradigm shift. Cancer Research 66, 1883-1890,2006. PMID:16488983.
36.Wang, L., Huang, Y., Sugimoto, Y., Liu, S., Chang, H., Ye, W., Shu, S., and Lin, Y. Conjugated linoleic acid (CLA) up-regulates the estrogenregulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTP gamma), in human breast cells. Anticancer Research 26, 27-34,2006. PMID:16475675.
37.Wang, L., Huang, Y., Liu, S., Chang, H., Ye, W., Shu, S., Sugimoto, Y., Funk, J., Smeak, D., Hill, L., and Lin, Y. Conjugated linoleic acid (CLA) modulates prostaglandin E-2 (PGE(2)) signaling in canine mammary cells. Anticancer Research 26, 889-898,2006. PMID:16619484.
38.Liu, S., Dontu, G., Mantle, I., Patel, S., Ahn, N., Jackson, K., Suri, P., and Wicha, M. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research 66, 6063-6071,2006. PMID:16778187.
39.Chang, H., Sugimoto, Y., Liu, S., Ye, W., Wang, L., Huang, Y., and Lin, Y. Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells. Anticancer Research 26, 1773-1784,2006. PMID:16827106.
40.Wang, L., Huang, Y., Sugimoto, Y., Liu, S., Chang, H., Ye, W., Shu, S., and Lin, Y. Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells. Anticancer Research 25, 4061-4068,2005. PMID:16312046.
41.Liu, S., Dontu, G., and Wicha, M. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Research 7, 86-95,2005. PMID:15987436.
42.Dontu, G., Liu, S., and Wicha, M. S. Stem cells in mammary development and carcinogenesis - Implications for prevention and treatment. Stem Cell Reviews 1, 207-213,2005. PMID:17142857.
43.Liu, S., Sugimoto, Y., Sorio, C., Tecchio, C., and Lin, Y. Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTP gamma) in human breast cancer cell line MCF-7. Oncogene 23, 1256-1262,2004. PMID:14676845.
44.Jiang, J., Sugimoto, Y., Liu, S., Chang, H., Park, K., Kulp, S., and Lin, Y. The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta, (TGF beta(1)) signal transduction pathway. Anticancer Research 24, 91-100,2004. PMID:15015581.
45.Liu, S. and Lin, Y. Transformation of MCF-10A human breast epithelial cells by zeranol and estradiol-17beta. The breast journal 10 (6): 514-521, 2004.
46.Liu, S., Sugimoto, Y., Kulp, S., Jiang, J., Chang, H., Park, K., Kashida, Y., and Lin, Y. Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. Anticancer Research 22, 3917-3923,2002. PMID:12553013.
47.Liu, S., Kulp, S., Sugimoto, Y., Jiang, J., Chang, H., and Lin, Y. Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTP gamma) mRNA expression by estrogenically active agents. Breast Cancer Research and Treatment 71, 21-35,2002. PMID:11859871.
48.Liu, S., Kulp, S., Sugimoto, Y., Jiang, J., Chang, H., Dowd, M., Wan, P., and Lin, Y. The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. Anticancer Research 22, 33-38,2002. PMID:12017312.
49.Jiang, J., Ghosh, P., Kulp, G., Sugimoto, Y., Liu, S., Czekajewski, J., Chang, H., and Lin, Y. Effects of gossypol on O-2 consumption and CO2 production in human prostate cancer cells. Anticancer Research 22, 1491-1496,2002. PMID:12168828.
50.Jiang, J., Kulp, S., Sugimoto, Y., Liu, S., and Lin, Y. The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats. Anticancer Research 20, 4591-4597,2000. PMID:11205308.
51.Du, R. and Liu S*. Applications of nanotechnology in targeting cancer stem cells. Chin Sci Bull, 2015, 60: 1
52.Ruan, D., Chen, J., Zhao, W., Liu, S., Gu, W. Effects of Lead on L-LTP and PPF in Hippocampal Dentate Gyrus. Guangdong Weiliang Yuansu Kexue 5: 25-29, 1998.Book Chapters
1.Xu, J., and Liu, S*. Non-coding RNAs in cancer cell plasticity.The long and shortnon-coding RNAs in cancer biology. Chapter 6, Page 137-172, 2016 (Springer).
2.Deng, L., Xu, J., Wang, D. and Liu, S*. Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesis. Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology, Chapter 6, Page 155-174, 2015.
3.Ouzounova, M., Liu, S*. and Wicha, M.S. Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives. Diseases of the breast, 5th edition, Chapter 2, Page 15-24, 2014.
4.Liu, Y. and Liu, S*. Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication. Stem Cells and Cancer Stem Cells Vol 10, 189-197, 2013.
5.Mantle, I., Dontu, G., Liu, S*. and Wicha, M.S. Cancer stem cells: implications for development of more effective therapies. Cancer drug resistance, PART II: Biological Resistance. 2005.
