Clinically, I have specialized in the field of surgery and chemotherapy for women with gynecologic cancers including cervical cancer, ovarian cancer, endometrial cancer, vulvar cancer, vaginal cancer, uterine sarcoma, vulvar or vaginal melanoma, et al. My main areas of surgical expertise are open or laparoscopic radical surgery for cervical cancer, endometrial cancer and vulvar cancer, staging surgery for early-stage ovarian cancer, optimal debulking surgery for advanced ovarian cancer and secondary debulking surgery for recurrent ovarian cancer. The debulking surgery involves removing not only the cancerous ovaries but as much other tissue that the cancer may have invaded as possible (such as in the spleen, liver, diaphram, portions of the bladder, bowel, and so on), which makes the tumor much more responsive to additional treatment. Each year, around 300 patients with newly diagnosed gynecologic cancers are undergone surgery by me, half of them receive adjuvant therapy. I have also been working closely with the radiotherapists in the treatment of advanced cervical cancer and recurrent gynecologic malignancies.

In addition, I am actively involved in clinical research to help determine the best treatments for patients with gynecologic cancers, including international multicenter randomized clinical trials of new drugs, prevention and screening program of HPV infection-associated cervical, vulvar and vaginal disease in general population, strategy identification for the treatment and follow-up of cervical precursors.

I have been doing basic research on molecular markers since 1995. I have grasped various molecular biological techniques including DNA、RNA and protein extraction, immunohistochemical staining, in situ hybridization, Western blot, Southern blot, Northern blot, PCR, real-time PCR, MSP, SSCP, DNA sequencing, Methylight, CGH, Microarray, cell culture, PCR cloning, ATP assay, Clongenic assay, MTT etc. My present major research projects include T regulatory cells in cervical carcinogenesis; identification and validation of novel genetic mutations in the cervical cancers and precursors, the viral mechanisms of evasion of the immune surveillance in patients with cervical cancers and precursors, epigenetic alterations in cervical carcinogenesis , progression and metastasis. My research is supported by funding from National Natural Science Foundation of China, Ministry of Health of the People’s Republic of China, Shanghai Municipal Natural Science Foundation, shanghai municipal health bureau.

In addition to caring for patients and conducting translational research, I am actively engaged in medical education and innovative technology. I have been the sponsor for 40 clinical fellows and the mentor for 7 postgraduates. I have authored or co-authored more than 30 peer-reviewed research papers and 4 book chapters. I serve on the reviewer of 2 international journals and 3 regional journals. My goals are to provide the highest quality comprehensive care to women with gynecologic cancers and improve patient outcomes through research and education.

Tuesday and Thursday