FIND DOCTORS
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Name: Wang, Mingwei
Department: NUCLEAR MEDICINE
Title:Education & Professional Experience 1. 2011.9—Present: Associate Professor, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center
2.2008.11—2010.4: Postdoctoral, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles (UCLA)
3. 2006.7—2011.8: Assistant Professor, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center
4. 2001.9—2006.6: Ph.D，Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Science
5. 1997.9—2001.7: BS, Department of Chemistry, Shaanxi Normal UniversitySpecialty 1.R&D of Radiopharmaceuticals, Radiolabeled Tracers, Radionuclide-based Molecular Imaging Probes for clinical diagnosis by PET/CT and SPECT/CT imaging and preclinical investigations by in vivo small animal PET/CT and SPECT/CT imaging;
2. [18F]Radiofluorination Chemistry for 18F-labeled (oncological) PET molecular imaging probes;
3. Automated Modular Synthesizers for R&D of 18F-labeled radiopharmaceuticals and molecular imaging probesResearch Interest of research: Radiopharmaceuticals, Molecular Imaging Probes, in vivo Small Animal Molecular Imaging (MicroPET/CT, NanoSPECT/CT, OI and CLI), Automated Synthesis Module (traditional technology-based bulky module and microfluidic chip-based tiny module)
2001-2006
Studies on PET imaging agents based on 18F-labeled amino acids, peptides and organic small molecular compounds, such as 18F-FET, 18F-VIP, 18F-DOPA, etc. Work with Prof. Duanzhi Yin and Prof, Yongxian Wang in Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences.
2006-2008
Studies on the R&D and automated production of PET radiopharmaceuticals i.e. PET molecular imaging probes, including 18F-FDG, 18F-FLT, 18F-FMISO, 18F-FES, 18F-FCH, 18F-FeCH, 18F-FAC, 18F-FHBG, 11C-Acetate, 11C-Choline, etc. Work with Prof. Yingjian Zhang, Associate Prof. Yongping Zhang, et al. in PET Center, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center.
2008-2010
Studies on oncologic molecular imaging using 18F-labeled tumor-specific proteins and antibodies (and fragments), such as PS-targeted 18F-Annexin B1 and 18F-Annexin V for apoptosis imaging, PSCA-targeted 18F-diabody for ImmunoPET imaging of prostate, and studies on fast and novel 18F-radiofluorination chemistry (including microwave-assisted chemistry and click/bioorthoganol chemistry, etc.) and automated synthesis technology (including microfluidic chip and traditional modular technology). Work with Assistant Prof. Clifton Kwang-Fu Shen in Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles (UCLA) and Work with Prof. Yingjian Zhang, Associate Prof. Yongping Zhang, et al. in PET Center, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center.
2010-
Studies on novel molecular imaging probes (18F-RGD, 18F-FT, 18F-ML-10, etc.), in vivo small animal molecular imaging (involved in MicroPET/CT, NanoSPECT/CT, OI and CLI), nanoparticle-based multifunctional theranostics for simultaneous treatment and diagnosis of cancer, 18F-radiofluorination chemistry and automated synthesis module technology. Work with Prof. Yingjian Zhang, Associate Prof. Yongping Zhang, et al. in PET Center, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, and collaborate with Assistant Prof. Clifton Kwang-Fu Shen in Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Prof. Xiaoyuan Chen in Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), et al.Publication [1] Wang M-W, Zhang Y-P, Zhang Y-J, Shen C. Module-assisted one-pot synthesis of [18F]SFB for radiolabeling proteins. J Radioanal Nucl Chem, 2011, 289(1): 191-196.
[2] Wang M-W, Lin W-Y L, Liu K, Masterman-Smith M, Shen C K-F. Microfluidics for Positron Emission Tomography Probe Development. Mol Imaging, 2010, 9(4): 175-191.
[3] Liu K, Lepin E J, Wang M-W, Guo F, Lin W-Y, Chen Y-C, Sirk S J, Olma S, Phelps M E, Zhao X-Z, Tseng H-R, van Dam R M, Wu A M, Shen C K-F. Microfluidic-Based 18F-Labeling of Biomolecules for Immuno-Positron Emission Tomography. Mol Imaging, 2011, 10(3): 168-176.
[4] Liu K, Wang M-W, Lin W-Y, Phung D L, D. Girgis M, M. Wu A, S. Tomlinson J, K.-F. Shen C. Molecular Imaging Probe Development Using Microfluidics. Curr Org Synth, 2011, 8(4): 473-487.
[5] Wang H, Liu K, Chen K-J, Lu Y, Wang S, Lin W-Y, Guo F, Kamei K-i, Chen Y-C, Ohashi M, Wang M, Garcia M A, Zhao X-Z, Shen C K F, Tseng H-R. A Rapid Pathway Toward a Superb Gene Delivery System: Programming Structural and Functional Diversity into a Supramolecular Nanoparticle Library. ACS Nano, 2010, 4(10): 6235-6243.
[6] Wang M, Zhang Y, Zhang Y, Yuan H. Automated synthesis of hypoxia imaging agent [18F]FMISO based upon a modified Explora FDG4 module. J Radioanal Nucl Chem, 2009, 280(1): 149-155.
[7] Wang M, Yin D, Li S, Wang Y. Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine and its biological evaluation in B16 melanoma-bearing mice as PET tracer for tumor imaging. Sci China Ser B-Chem, 2007, 50(2): 276-283.
[8] Cheng D, Yin D, Zhang L, Wang M, Li G, Wang Y. Preparation of the novel fluorine-18-labeled VIP analog for PET imaging studies using two different synthesis methods. J Fluorine Chem, 2007, 128(3): 196-201.
[9]Cheng D, Yin D, Zhang L, Wang M, Li G, Wang Y. Radiosynthesis of 18F-(R8,15,21, L17)-vasoactive intestinal peptide and preliminary evaluation in mice bearing C26 colorectal tumours. Nucl Med Commun, 2007, 28(6): 501-506.
[10] Li G, Yin D, Wang M, Cheng D, Wang Y. Synthesis of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones. Radiochim Acta 2006: 94: 119-122.
[11] Tian HB, Yin DZ, Zhang L, Wang LH, Zhang CF, Wang MW, Wu CY, Li GC, Wang YX. Dopamine D4 receptor antagonist 3-(4-[18F]fluorobenzyl)-8-methoxy-1,2,3,4-tetrahydro- chromeno[3,4-c]pyridine-5-one ([18F]FMTP): radiosynthesis and in vivo characterization in rats.. Appl Radiat Isot 2005; 63: 333-342.
Awards 1. The Excellence Award for poster presentation in 9th national annual meeting of Chinese Society of Nuclear Medicine, 2011
2. Award of Recognition in the annual meeting of Shanghai Society of Nuclear Medicine, 2011
3. 3rd Award for poster presentation in 4th national youth meeting of Chinese Society of Nuclear Medicine, 2008
